CAS No. 65182-56-1
Batch:
Purity:99.78
Chemical Structure
Check the
2-NP
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 65182-56-1 | |
|---|---|---|
| Molecular Formula |
C14H10N2O |
|
| Molecular Weight (MW) | 222.24 |
2-NP is a synthetic small molecule that acts as a selective enhancer of STAT1 transcription. By enhancing STAT1-mediated transcriptional activation, 2-NP potentiates the downstream signaling of the interferon-gamma (IFN-γ) pathway. This augmentation leads to enhanced antiproliferative responses in cancer cells, including human breast cancer and fibrosarcoma models, through modulation of STAT1-dependent gene expression. [1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
22 mg/mL
(98.99 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 5 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.