CAS No. 579-75-9

Batch: Purity:99.88
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2-Methoxybenzoic acid Chemical Structure
Chemical Structure
Check the 2-Methoxybenzoic acid product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 579-75-9
Molecular Formula

C8H8O3
Molecular Weight (MW) 152.15
SMILES COC1=CC=CC=C1C(=O)O

Biological Activity

2-Methoxybenzoic acid (o-anisic acid) is a benzoic acid derivative and flavoring agent that functions as a small-molecule inhibitor of tyrosinase. By targeting the tyrosinase enzyme, 2-methoxybenzoic acid suppresses monophenolase and diphenolase catalytic activities, thereby blocking downstream melanin biosynthesis. In cellular and biochemical contexts, this inhibition modulates melanogenesis and cellular response pathways associated with oxidative stress and pigment formation. [1][2]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 30 mg/mL (197.17 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Chang TS. Int J Mol Sci. 2009;10(6):2440-2475.

[2] Pillaiyar T, et al. Drug Discov Today. 2017;22(2):282-298.

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Note: Technical data last updated: Sep 1, 2026.