CAS No. 932-30-9

Batch: Purity:99.82
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2-Hydroxybenzylamine Chemical Structure
Chemical Structure
Check the 2-Hydroxybenzylamine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-(aminomethyl)phenol
CAS Number 932-30-9
Molecular Formula

C7H9NO
Molecular Weight (MW) 123.15
SMILES NCC1=CC=CC=C1O
InChIKey KPRZOPQOBJRYSW-UHFFFAOYSA-N

Ordering Information

Biological Activity

2-Hydroxybenzylamine (2-HOBA) is a naturally occurring small-molecule scavenger that selectively reacts with lipid-derived reactive dicarbonyl electrophiles, including isoketals and malondialdehyde. By rapidly sequestering these reactive dicarbonyl species before they adduct to cellular proteins and lipids, 2-HOBA prevents oxidative stress-induced cell damage. This protective activity mitigates inflammatory pathways, reduces apoptotic cells within vascular lesions, enhances macrophage efferocytosis, and promotes structural features of plaque stability.

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 25 mg/mL (203.0 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 25 mg/mL
Water 4 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.