CAS No. 42155-08-8
Batch:
Purity:99.93
Chemical Structure
Check the
2'-Deoxyuridine 5'-monophosphate disodium salt
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | disodium;[(2R,3S,5R)-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methyl phosphate | |
|---|---|---|
| CAS Number | 42155-08-8 | |
| Molecular Formula |
C9H11N2Na2O8P |
|
| Molecular Weight (MW) | 352.15 | |
| SMILES | [Na+].[Na+].OC1CC(OC1CO[P]([O-])([O-])=O)N2C=CC(=O)NC2=O | |
| InChIKey | FXVXMLXAXVVONE-CDNBRZBRSA-L |
2'-Deoxyuridine 5'-monophosphate disodium salt (dUMP) acts as a native nucleotide substrate for thymidylate synthase, undergoing reductive methylation to yield 2'-deoxythymidine 5'-monophosphate (dTMP). This enzymatically catalyzed conversion is essential for the de novo synthesis of thymidine nucleotides required for DNA replication and repair. Modulation of dUMP methylation directly regulates pyrimidine biosynthesis, governing cellular proliferation in both prokaryotic and eukaryotic organisms. [1][2]
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Concentration
Volume
Mass
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|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| Water | 70 mg/mL |
| DMSO |
20 mg/mL
(56.79 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
- 2'-Deoxyuridine 5'-monophosphate disodium salt Clinical Trials
- 2'-Deoxyuridine 5'-monophosphate disodium salt Solubility in DMSO
- 2'-Deoxyuridine 5'-monophosphate disodium salt Stock Solution
- 2'-Deoxyuridine 5'-monophosphate disodium salt Storage
- 2'-Deoxyuridine 5'-monophosphate disodium salt Stability
- 2'-Deoxyuridine 5'-monophosphate disodium salt Molecular Weight
- 2'-Deoxyuridine 5'-monophosphate disodium salt SMILES
- 2'-Deoxyuridine 5'-monophosphate disodium salt Chemical Structure (2D and 3D)
- 2'-Deoxyuridine 5'-monophosphate disodium salt SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.