CAS No. 84946-20-3

Batch: Purity:98
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2-Chloro-1-(4-fluorobenzyl)benzimidazole Chemical Structure
Chemical Structure
Check the 2-Chloro-1-(4-fluorobenzyl)benzimidazole product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-chloro-1-[(4-fluorophenyl)methyl]benzimidazole
CAS Number 84946-20-3
Molecular Formula

C14H10ClFN2
Molecular Weight (MW) 260.69
SMILES C1=CC=C2C(=C1)N=C(N2CC3=CC=C(C=C3)F)Cl
InChIKey PGXALMVNIRPELS-UHFFFAOYSA-N

Ordering Information

Biological Activity

2-Chloro-1-(4-fluorobenzyl)benzimidazole is a benzimidazole derivative and synthetic intermediate that acts as an aldose reductase (ALR2) inhibitor. By inhibiting ALR2, it modulates the polyol pathway, which catalyzes the reduction of glucose to sorbitol. Polyol pathway inhibition reduces intracellular sorbitol accumulation and associated osmotic stress, playing a key role in mitigating diabetic microvascular complications. [1]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 52 mg/mL (199.47 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.