CAS No. 15397-12-3
Batch:
Purity:97.30
Chemical Structure
Check the
2'-C-Methyladenosine
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)-3-methyloxolane-3,4-diol | |
|---|---|---|
| CAS Number | 15397-12-3 | |
| Molecular Formula |
C11H15N5O4 |
|
| Molecular Weight (MW) | 281.27 | |
| InChIKey | PASOFFRBGIVJET-YRKGHMEHSA-N |
2'-C-Methyladenosine is a nucleoside analog and inhibitor of hepatitis C virus (HCV) replication with an IC50 of 0.3 µM in Huh-7 cells. Intracellularly, it is converted to 2'-C-methyladenosine triphosphate, which acts as a chain terminator and directly inhibits HCV NS5B RNA-dependent RNA polymerase with an IC50 of 1.9 µM. This blockade suppresses viral RNA synthesis and inhibits replicon propagation. [1]
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Concentration
Volume
Mass
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Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
56 mg/mL
(199.09 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.