CAS No. 3306-62-5

Batch: Purity:99.86
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2-Aminobenzenesulfonamide Chemical Structure
Chemical Structure
Check the 2-Aminobenzenesulfonamide product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2-aminobenzenesulfonamide
CAS Number 3306-62-5
Molecular Formula

C6H8N2O2S
Molecular Weight (MW) 172.20
SMILES C1=CC=C(C(=C1)N)S(=O)(=O)N
InChIKey YAZSBRQTAHVVGE-UHFFFAOYSA-N

Ordering Information

Biological Activity

2-Aminobenzenesulfonamide is a primary sulfonamide inhibitor targeting carbonic anhydrase IX (CAIX/CA9). By suppressing carbonic anhydrase activity, it impairs the reversible hydration of carbon dioxide to bicarbonate and protons, disrupting extracellular pH regulation and hypoxia adaptation. Consequently, inhibition of CAIX alters cellular pH homeostasis, reducing cancer cell survival, proliferation, and invasive capability within hypoxic tumor microenvironments.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 34 mg/mL (197.44 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.