CAS No. 56-06-4

Batch: Purity:99.91
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2,4-Diamino-6-hydroxypyrimidine Chemical Structure
Chemical Structure
Check the 2,4-Diamino-6-hydroxypyrimidine product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 2,4-diamino-1H-pyrimidin-6-one
CAS Number 56-06-4
Molecular Formula

C4H6N4O
Molecular Weight (MW) 126.12
SMILES C1=C(N=C(NC1=O)N)N
InChIKey SWELIMKTDYHAOY-UHFFFAOYSA-N

Ordering Information

Biological Activity

2,4-Diamino-6-hydroxypyrimidine (DAHP) is a selective inhibitor of GTP cyclohydrolase I (GCH1), which serves as the rate-limiting enzyme in de novo pterin biosynthesis. By blocking GCH1 activity, DAHP depletes intracellular tetrahydrobiopterin (BH4), an essential cofactor for nitric oxide synthases. This intracellular BH4 depletion subsequently suppresses cellular nitric oxide production and attenuates cytokine-induced vascular smooth muscle signaling responses.

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 25 mg/mL (198.22 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 6 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.