CAS No. 2734858-36-5

Batch: Purity:99.83
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2',3'-cGAMP Sodium Salt Chemical Structure
Chemical Structure
Check the 2',3'-cGAMP Sodium Salt product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name disodium;2-amino-9-[(1R,6R,8R,9R,10S,15R,17R,18R)-8-(6-aminopurin-9-yl)-9,18-dihydroxy-3,12-dioxido-3,12-dioxo-2,4,7,11,13,16-hexaoxa-3λ5,12λ5-diphosphatricyclo[13.2.1.06,10]octadecan-17-yl]-1H-purin-6-one
CAS Number 2734858-36-5
Molecular Formula

C20H22N10Na2O13P2
Molecular Weight (MW) 718.37
InChIKey CNVCOPPPOWRJAV-DQNSRKNCSA-L

Ordering Information

Biological Activity

2',3'-cGAMP Sodium Salt is an endogenous cyclic dinucleotide second messenger and potent agonist of the STING (stimulator of interferon genes) receptor. Upon binding to STING, 2',3'-cGAMP induces conformational changes that activate downstream TBK1 and IRF3 signaling pathways. This cascades into the robust induction of type I interferons, such as IFN-β, and pro-inflammatory cytokines, enhancing innate immune responses against cytosolic DNA and pathogens. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (139.2 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.