CAS No. 131-53-3
Batch:
Purity:99.89
Chemical Structure
Check the
2,2′-Dihydroxy-4-methoxybenzophenone
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 131-53-3 | |
|---|---|---|
| Molecular Formula |
C14H12O4 |
|
| Molecular Weight (MW) | 244.24 | |
| SMILES | COC1=CC(=C(C=C1)C(=O)C2=CC=CC=C2O)O |
Biological Activity
2,2′-Dihydroxy-4-methoxybenzophenone (Dioxybenzone) is a benzophenone-derived organic ultraviolet (UV) filter that absorbs UVB and short-wave UVA radiation. By attenuating UV energy absorption, it reduces UV-induced cellular photo-damage and reactive oxygen species generation, protecting skin cells against oxidative stress and DNA photo-lesions. Additionally, benzophenone derivatives exhibit weak endocrine-modulating activities within estrogenic signaling pathways.
How to Prepare Stock Solution?
|
Concentration
Volume
Mass
|
|---|
Solubility
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
48 mg/mL
(196.52 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 48 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Jump to
- 2,2′-Dihydroxy-4-methoxybenzophenone Solubility in DMSO
- 2,2′-Dihydroxy-4-methoxybenzophenone Stock Solution
- 2,2′-Dihydroxy-4-methoxybenzophenone Storage
- 2,2′-Dihydroxy-4-methoxybenzophenone Stability
- 2,2′-Dihydroxy-4-methoxybenzophenone Molecular Weight
- 2,2′-Dihydroxy-4-methoxybenzophenone SMILES
- 2,2′-Dihydroxy-4-methoxybenzophenone Chemical Structure (2D and 3D)
- 2,2′-Dihydroxy-4-methoxybenzophenone SDS｜MSDS
Note: Technical data last updated: Sep 1, 2026.