CAS No. 1430208-73-3
Batch:
Purity:99.97
Chemical Structure
Check the
1A-116
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-(3,5-dimethylphenyl)-2-[2-(trifluoromethyl)phenyl]guanidine | |
|---|---|---|
| CAS Number | 1430208-73-3 | |
| Molecular Formula |
C16H16F3N3 |
|
| Molecular Weight (MW) | 307.31 | |
| SMILES | CC1=CC(=CC(=C1)NC(=N)NC2=C(C=CC=C2)C(F)(F)F)C | |
| InChIKey | DVIJFJSZZNOTLP-UHFFFAOYSA-N |
1A-116 is a small-molecule Rac1 inhibitor that targets Rac1-GEF signaling interactions. By blocking guanine nucleotide exchange factor-mediated Rac1 activation, it impairs downstream actin cytoskeleton reorganization, membrane ruffling, and lamellipodia formation. Consequently, 1A-116 suppresses cell proliferation, migration, and cycle progression while promoting apoptotic pathways, resulting in marked antitumoral and antimetastatic effects across multiple malignancies, including breast cancer.[1][2]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
61 mg/mL
(198.49 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 61 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.