CAS No. 387-79-1

Batch: Purity:
17-OH PREG (17a-Hydroxypregnenolone) Chemical Structure
Chemical Structure
Check the 17-OH PREG (17a-Hydroxypregnenolone) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 387-79-1
Molecular Formula

C21H32O3
Molecular Weight (MW) 332.48

Biological Activity

17α-Hydroxypregnenolone is a natural steroidogenesis intermediate and precursor to dehydroepiandrosterone (DHEA), produced from pregnenolone via cytochrome P450 17A1 (CYP17A1) hydroxylase activity. Within the adrenal cortex and gonads, it undergoes 17,20-lyase cleavage to yield DHEA or conversion by 3β-hydroxysteroid dehydrogenase to 17α-hydroxyprogesterone. Elevated plasma levels of this steroid metabolite serve as a diagnostic hallmark for type II 3β-hydroxysteroid dehydrogenase deficiency. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
🧮 Molarity Calculator

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Miller WL, et al. Endocr Rev. 2011;32(1):81-151.

Jump to

Note: Technical data last updated: Sep 1, 2026.