CAS No. 42895-58-9

Batch: Purity:99.57
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14-Deoxy-11,12-didehydroandrographolide Chemical Structure
Chemical Structure
Check the 14-Deoxy-11,12-didehydroandrographolide product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 42895-58-9
Molecular Formula

C20H28O4
Molecular Weight (MW) 332.43
SMILES CC1(CO)C(O)CCC2(C)C1CCC(=C)C2/C=C/C3=CCOC3=O

Ordering Information

Biological Activity

14-Deoxy-11,12-didehydroandrographolide (deAND) is a natural labdane diterpenoid isolated from Andrographis paniculata with anti-inflammatory and antiviral activities. It inhibits the NF-κB signaling pathway by suppressing p65 nuclear translocation, thereby reducing pro-inflammatory cytokines such as IL-4, IL-5, and IL-13 and mitigating allergic airway inflammation. Additionally, deAND attenuates excessive inflammatory cytokine release and restrains viral replication during influenza A virus infection. [1][2]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 66 mg/mL (198.53 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.