CAS No. 413611-93-5
Batch:
Purity:99.44
Chemical Structure
Check the
10074-G5
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 4-nitro-N-(2-phenylphenyl)-2,1,3-benzoxadiazol-7-amine | |
|---|---|---|
| CAS Number | 413611-93-5 | |
| Molecular Formula |
C18H12N4O3 |
|
| Molecular Weight (MW) | 332.31 | |
| SMILES | C1=CC=C(C=C1)C2=CC=CC=C2NC3=CC=C(C4=NON=C34)[N+](=O)[O-] | |
| InChIKey | KMJPYSQOCBYMCF-UHFFFAOYSA-N |
10074-G5 is a c-Myc inhibitor that binds to the bHLH-ZIP domain of c-Myc (Kd 2.8 µM) and inhibits c-Myc/Max transcriptional activity (IC50 146 µM). By disrupting c-Myc/Max heterodimer formation, 10074-G5 impairs c-Myc-driven transcriptional programs. Disruption of c-Myc pathway signaling leads to reduced cellular proliferation and the suppression of oncogenic phenotypes in c-Myc-dependent tumor cells.
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
66 mg/mL
(198.6 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 8 mg/mL |
| Water | Insoluble |
| DMSO |
66 mg/mL
(198.6 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 10 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Pre-aliquoted for Longevity: Solid-state aliquots offer significantly longer shelf life compared to stock solutions, ensuring maximum stability for every use.
Looking for a specific aliquot size? Reach out to your local sales representative or contact us at orders@selleckchem.com.
Note: Technical data last updated: Sep 1, 2026.