CAS No. 32981-86-5

Batch: Purity:99.90
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10-Deacetylbaccatin-III Chemical Structure
Chemical Structure
Check the 10-Deacetylbaccatin-III product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name [(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-1,9,12,15-tetrahydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate
CAS Number 32981-86-5
Molecular Formula

C29H36O10
Molecular Weight (MW) 544.59
SMILES CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1O)O)OC(=O)C5=CC=CC=C5)(CO4)OC(=O)C)O)C)O
InChIKey YWLXLRUDGLRYDR-ZHPRIASZSA-N

Ordering Information

Biological Activity

10-Deacetylbaccatin-III is a naturally occurring taxane derivative and antineoplastic agent that acts as a key intermediate for taxane biosynthesis and semi-synthesis. It targets tubulin to promote microtubule assembly and stabilization, thereby disrupting dynamic instability required for mitotic spindle formation. This microtubule stabilization inhibits cancer cell proliferation and induces cell cycle arrest and apoptosis across various tumor cell lines.

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (183.62 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.