CAS No. 96-27-5

1-Thioglycerol Chemical Structure
Chemical Structure
Check the 1-Thioglycerol product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 3-sulfanylpropane-1,2-diol
CAS Number 96-27-5
Molecular Formula

C3H8O2S

Molecular Weight (MW) 108.16
InChIKey PJUIMOJAAPLTRJ-UHFFFAOYSA-N

Biological Activity

1-Thioglycerol is a small-molecule thiol compound and competitive inhibitor of glycerol kinase activity. By targeting glycerol kinase, it suppresses intracellular glycerol utilization and modulates lipid metabolic pathways in host cells. Additionally, treatment with 1-thioglycerol stimulates porphyrin biosynthesis and secretion in aerobically growing Escherichia coli through the upregulation of glutamyl-tRNA reductase activity dependent on de novo protein synthesis.[1][2]

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Note: Technical data last updated: Sep 1, 2026.