CAS No. 103-85-5
Batch:
Purity:99.54
Chemical Structure
Check the
1-PHENYL-2-THIOUREA
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | phenylthiourea | |
|---|---|---|
| CAS Number | 103-85-5 | |
| Molecular Formula |
C7H8N2S |
|
| Molecular Weight (MW) | 152.22 | |
| InChIKey | FULZLIGZKMKICU-UHFFFAOYSA-N |
1-Phenyl-2-thiourea is a tyrosinase inhibitor that suppresses melanogenesis and blocks pigment formation during organismal development. By inhibiting tyrosinase-mediated melanin synthesis pathways, 1-phenyl-2-thiourea enhances optical transparency in developing zebrafish embryos for imaging applications. Additionally, 1-phenyl-2-thiourea exposure activates macroautophagy signaling cascades and disrupts thyroid hormone synthesis, leading to affected developmental phenotypes and altered thyroid function in embryonic models.[1][2]
|
Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
30 mg/mL
(197.08 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 30 mg/mL |
| Water | Insoluble |
| DMSO |
30 mg/mL
(197.08 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Ethanol | 15 mg/mL |
| Water | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.