CAS No. 221244-14-0
Batch:
Purity:99.35
Chemical Structure
Check the
1-NM-PP1
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | 1-tert-butyl-3-(naphthalen-1-ylmethyl)pyrazolo[3,4-d]pyrimidin-4-amine | |
|---|---|---|
| CAS Number | 221244-14-0 | |
| Molecular Formula |
C20H21N5 |
|
| Molecular Weight (MW) | 331.41 | |
| SMILES | CC(C)(C)[N]1N=C(CC2=CC=CC3=CC=CC=C23)C4=C(N)N=CN=C14 | |
| InChIKey | GDQXJQSQYMMKRA-UHFFFAOYSA-N |
1-NM-PP1 is a potent, cell-permeable inhibitor of engineered analog-sensitive protein kinases, specifically targeting mutant alleles such as v-Src-as1, c-Fyn-as1, CDK2-as1, CAMKII-as1, and c-Abl-as2. By selectively binding to the expanded ATP-binding pocket of analog-sensitive kinase mutants, 1-NM-PP1 blocks ATP access and disrupts downstream kinase signaling pathways. This inhibition enables precise functional dissection of specific kinase activities, regulating downstream cellular processes such as cell proliferation and signal transduction. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
66 mg/mL
(199.14 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | Insoluble |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.