CAS No. 154-58-5

Batch: Purity:99.18
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1,5-Anhydro-D-glucitol Chemical Structure
Chemical Structure
Check the 1,5-Anhydro-D-glucitol product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 154-58-5
Molecular Formula

C6H12O5
Molecular Weight (MW) 164.16
SMILES OCC1OCC(O)C(O)C1O

Ordering Information

Biological Activity

1,5-Anhydro-D-glucitol is a naturally occurring monosaccharide and metabolically inert polyol derived mainly from dietary sources. Reabsorbed in renal proximal tubules under normoglycemic conditions, it competes with glucose for renal reabsorption. During hyperglycemia, glucosuria competitively inhibits its tubular reabsorption, leading to rapid renal excretion and depleted serum levels. Consequently, serum concentrations serve as a clinical biomarker for monitoring short-term glycemic control.[1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (609.16 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol 33 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.