CAS No. 1448189-80-7

Batch: Purity:99.67
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(S,R,S)-AHPC hydrochloride Chemical Structure
Chemical Structure
Check the (S,R,S)-AHPC hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 1448189-80-7
Molecular Formula

C22H30N4O3S.CIH
Molecular Weight (MW) 467.03
SMILES CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)N)O.Cl

Ordering Information

Biological Activity

(S,R,S)-AHPC hydrochloride is a high-affinity von Hippel-Lindau (VHL) E3 ubiquitin ligase ligand designed for the recruitment of the VHL protein. Conjugation of this functionalized ligand to target-binding molecules via linkers enables the synthesis of proteolysis targeting chimeras (PROTACs). These bifunctional molecules induce target protein ubiquitination by recruiting the VHL E3 ubiquitin ligase complex, leading to selective protein degradation via the ubiquitin-proteasome pathway in targeted protein degradation research. [1][2]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 93 mg/mL (199.13 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 93 mg/mL
Ethanol 93 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.