CAS No. 121917-57-5

Batch: Purity:99.96
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(-)-Dizocilpine (MK 801) Maleate Chemical Structure
Chemical Structure
Check the (-)-Dizocilpine (MK 801) Maleate product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (Z)-but-2-enedioic acid;(1R,9S)-1-methyl-16-azatetracyclo[7.6.1.02,7.010,15]hexadeca-2,4,6,10,12,14-hexaene
CAS Number 121917-57-5
Molecular Formula

C16H15N.C4H4O4
Molecular Weight (MW) 337.37
SMILES CC12C3=CC=CC=C3CC(N1)C4=CC=CC=C24.C(=CC(=O)O)C(=O)O
InChIKey QLTXKCWMEZIHBJ-FWHYOZOBSA-N

Ordering Information

Biological Activity

(-)-Dizocilpine (MK-801) maleate is a potent, noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist. Selective channel blockade of ionotropic NMDA receptors suppresses glutamate-stimulated intracellular calcium influx and downstream excitatory neurotransmission. This targeted inhibition attenuates glutamatergic signaling, altering synaptic plasticity and neural network activity while demonstrating neuroprotective and anticonvulsant effects in central nervous system study models. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 67 mg/mL (198.59 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 7 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.