CAS No. 5984-95-2

Batch: Purity:99.46
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(-)-Isoproterenol hydrochloride Chemical Structure
Chemical Structure
Check the (-)-Isoproterenol hydrochloride product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name 4-[(1R)-1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,2-diol;hydrochloride
CAS Number 5984-95-2
Molecular Formula

C11H17NO3.CIH
Molecular Weight (MW) 247.72
InChIKey IROWCYIEJAOFOW-MERQFXBCSA-N

Biological Activity

(-)-Isoproterenol hydrochloride is a potent, non-selective agonist targeting β-adrenergic receptors. Agonist activation of these receptors stimulates adenylyl cyclase activity to markedly increase intracellular cyclic AMP (cAMP) levels. Downstream cAMP-dependent signaling engages the AKT and ERK/MAPK pathways while inhibiting interleukin-dependent JAK/STAT signaling, leading to modulated physiological phenotypes such as cell survival, proliferation, and lymphocyte immune responses.[1][2]

How to Prepare Stock Solution?

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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 50 mg/mL (201.84 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 50 mg/mL
Ethanol 8 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Ruiz-Medina BE, et al. J Biol Chem. 2015;290(34):20972-20983.

[2] Ruiz-Medina BE, et al. Biochem J. 2018;475(18):2907-2923.

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Note: Technical data last updated: Sep 1, 2026.