CAS No. 2023788-19-2 (free base)

Batch: Purity:99.96
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Tirzepatide (LY3298176) sodium Chemical Structure
Chemical Structure
Check the Tirzepatide (LY3298176) sodium product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 2023788-19-2 (free base)
Molecular Formula

C225H348N48O68• XNa
Molecular Weight (MW) 4813.45

Ordering Information

Biological Activity

Tirzepatide sodium is a synthetic dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist. Activation of GIP and GLP-1 receptors stimulates cAMP signaling pathways, which enhances glucose-dependent insulin secretion, improves glycemic control, and regulates lipid metabolism. Furthermore, agonist engagement differentially promotes receptor internalization and downstream endosomal signaling, leading to sustained metabolic regulation in preclinical cell and animal models. [1][2]

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (20.77 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 3 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.