CAS No. 148470-19-3

Batch: Purity:99.98
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Substance P TFA Chemical Structure
Chemical Structure
Check the Substance P TFA product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (2S)-2-[[(2S)-1-[(2S)-6-amino-2-[[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-N-[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-1,5-dioxopentan-2-yl]pentanediamide;2,2,2-trifluoroacetic acid
CAS Number 148470-19-3
Molecular Formula

C63H98N18O13S.C2HF3O2
Molecular Weight (MW) 1461.67
InChIKey HJUBUMANGKVTGH-HDKZLILXSA-N

Ordering Information

Biological Activity

Substance P TFA is an endogenous neuropeptide that acts as an agonist for the neurokinin 1 receptor (NK1R) in the central and peripheral nervous systems. Upon binding to NK1R, it modulates tachykinin signaling pathways to mediate neurotransmission and neuromodulation. These cellular actions play key roles in regulating nociceptive pain signal processing, neurogenic inflammation, smooth muscle contraction, and emotional behavior. [1]

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (68.41 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol 100 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.