CAS No. 2381089-83-2

Batch: Purity:99.72
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Retatrutide (LY3437943) Chemical Structure
Chemical Structure
Check the Retatrutide (LY3437943) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 2381089-83-2
Molecular Formula

C221H342N46O68

Ordering Information

Biological Activity

Retatrutide (LY3437943) is a peptide triple agonist of the glucose-dependent insulinotropic polypeptide receptor (GIPR, EC50 =, glucagon-like peptide-1 receptor (GLP-1R, EC50 =, and glucagon receptor (GCGR, EC50 =. Activation of these receptors stimulates insulin secretion, improves glycemic control, and increases energy expenditure via cAMP-dependent signaling pathways. Downstream phenotypes include significant reduction in body weight and enhanced metabolic homeostasis. [1]

Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.)
Water 100 mg/mL
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.