CAS No. 124584-08-3
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Nesiritide
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
Chemical Information
| CAS Number | 124584-08-3 | |
|---|---|---|
| Molecular Formula |
C143H244N50O42S4 |
|
| Molecular Weight (MW) | 3464.04 |
Biological Activity
Nesiritide (Brain Natriuretic Peptide-32 human) is a peptide agonist of natriuretic peptide receptors, exhibiting selective activity toward natriuretic peptide receptor-A (NPR-A). Upon binding NPR-A, Nesiritide activates particulate guanylyl cyclase to elevate intracellular cyclic guanosine monophosphate (cGMP) levels. This activation triggers downstream cGMP-dependent signaling pathways that promote vascular smooth muscle relaxation, induce vasodilation, and modulate cellular fluid and electrolyte homeostasis. [1]
How to Prepare Stock Solution?
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Note: Technical data last updated: Sep 1, 2026.