CAS No. 182683-50-7
Batch:
Purity:98.72
Chemical Structure
Check the
Epsilon-V1-2
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| IUPAC Name | (4S)-4-amino-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[(2S)-2-[[(1S,2R)-1-carboxy-2-hydroxypropyl]carbamoyl]pyrrolidin-1-yl]-1-oxohexan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoic acid | |
|---|---|---|
| CAS Number | 182683-50-7 | |
| Molecular Formula |
C37H65N9O13 |
|
| Molecular Weight (MW) | 843.97 | |
| SMILES | CC(C)CC(NC(=O)C(CO)NC(=O)C(NC(=O)C(C)NC(=O)C(N)CCC(O)=O)C(C)C)C(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)NC(C(C)O)C(O)=O | |
| InChIKey | KNTBAGOTDJPUJV-XMTFRXHISA-N |
Epsilon-V1-2 is a selective peptide inhibitor of protein kinase C epsilon (PKCε) that selectively blocks the translocation of PKCε. By inhibiting PKCε translocation without affecting α-, β-, or δ-PKC isozymes, Epsilon-V1-2 attenuates downstream PKCε-mediated signaling pathways. This targeted inhibition suppresses phorbol ester-induced enzyme activation and modulates critical downstream functions, including protecting cardiac myocytes against ischemic cellular injury. [1]
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Concentration
Volume
Mass
|
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(118.48 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | 100 mg/mL |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.