CAS No. 149155-45-3
Batch:
Purity:98.96
Chemical Structure
Check the
CREBtide
product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.
| CAS Number | 149155-45-3 | |
|---|---|---|
| Molecular Formula |
C73H129N29O19 |
|
| Molecular Weight (MW) | 1716.99 | |
| SMILES | CCC(C)C(NC(=O)C(CCC(O)=O)NC(=O)C(CCCN=C(N)N)NC(=O)C(CCCN=C(N)N)NC(=O)C(N)CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(CCCN=C(N)N)C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NC(CO)C(=O)NC(CC2=CC=C(O)C=C2)C(=O)NC(CCCN=C(N)N)C(O)=O |
CREBtide is a synthetic 13-amino acid peptide that acts as a specific substrate for protein kinase A (PKA). Phosphorylation of CREBtide by PKA enables the quantitative assessment of cAMP-dependent protein kinase activity. PKA-mediated phosphorylation regulates key downstream signaling pathways, controlling cAMP-responsive gene transcription, cellular metabolism, and physiological responses to second messenger signaling. [1]
|
Concentration
Volume
Mass
|
1 mg | 5 mg | 10 mg |
|---|
Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
| Solvent | Solubility & Note |
|---|---|
| DMSO |
100 mg/mL
(58.24 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.) |
| Water | 100 mg/mL |
| Ethanol | Insoluble |
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
- Preheat media/saline to 37°C.
- Mix rapidly (pipette/vortex) upon addition.
- For complex mixes, always add the aqueous phase last.
- Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).
Note: Technical data last updated: Sep 1, 2026.