research use only

CIRC-014

Cat.No.P1267

CIRC-014 is an orally bioavailable cyclin A/B RxL macrocyclic inhibitor. CIRC-014 displays robust anti-tumor activity in chemo-resistant small cell lung cancer (SCLC) PDX models and induces SAC activation and apoptosis in vivo.

Amino-acid Sequence

CAS No.

Quality Control

Featured Inhibitors	Y-27632 Dihydrochloride SB431542 CHIR-99021 (Laduviglusib) RMC-7977 RMC-6236 (Daraxonrasib) MRTX1133 MG132 Z-VAD-FMK VT3989 IAG933

Chemical Information & Solubility

Storage (From the date of receipt)	3 years-20°Cpowder	Storage of Stock Solutions Aliquot the stock solutions to avoid repeated freeze-thaw cycles	1 year-80°Cin solvent
			1 month-20°Cin solvent

In vivo
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Biological Activity

Description	CIRC-014 is an orally bioavailable cyclin A/B RxL macrocyclic inhibitor. CIRC-014 displays robust anti-tumor activity in chemo-resistant small cell lung cancer (SCLC) PDX models and induces SAC activation and apoptosis in vivo.

References
https://pubmed.ncbi.nlm.nih.gov/39211113/

References

https://pubmed.ncbi.nlm.nih.gov/39211113/

Product Information

Shipping	Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)