CAS No. 2408921-49-1

Batch: Purity:95.67
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Brenipatide Chemical Structure
Chemical Structure
Check the Brenipatide product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

CAS Number 2408921-49-1
Molecular Formula

C228H354N46O72
Molecular Weight (MW) 4891.52

Biological Activity

Brenipatide is a dual glucagon-like peptide-1 receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR) agonist. By activating both GLP-1R and GIPR signaling pathways, dual co-agonists regulate metabolic homeostasis, enhance insulin secretion, and modulate central reward pathways involved in psychiatric and addiction disorders. Dual targeting of GLP-1R and GIPR provides enhanced metabolic control and neurobehavioral efficacy compared to single-receptor targeting strategies. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (20.44 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Ethanol 100 mg/mL
Water Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Nat Med. 2013;19(5):515-515.

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Note: Technical data last updated: Sep 1, 2026.