CAS No. 412961-36-5

Batch: Purity:99.91
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BAM (8-22) Chemical Structure
Chemical Structure
Check the BAM (8-22) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (4S)-5-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-amino-1-[[(2S)-6-amino-1-[[(2S)-5-carbamimidamido-1-[[(2S)-1-(carboxymethylamino)-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-1,5-dioxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-[[(2S)-1-[(2S)-2-[[2-[[(2S)-2-amino-3-methylbutanoyl]amino]acetyl]amino]-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoic acid
CAS Number 412961-36-5
Molecular Formula

C91H127N25O23S
Molecular Weight (MW) 1971.21
SMILES CSCCC(NC(=O)C(CC1=C[NH]C2=CC=CC=C12)NC(=O)C(CC3=C[NH]C4=CC=CC=C34)NC(=O)C(CCC(O)=O)NC(=O)C5CCCN5C(=O)C(CCCNC(N)=N)NC(=O)CNC(=O)C(N)C(C)C)C(=O)NC(CC(O)=O)C(=O)NC(CC6=CC=C(O)C=C6)C(=O)NC(CCC(N)=O)C(=O)NC(CCCCN)C(=O)NC(CCCNC(N)=N)C(=O)NC(CC7=CC=C(O)C=C7)C(=O)NCC(O)=O
InChIKey GOEYECACIBFJGZ-NPAGUKBMSA-N

Ordering Information

Biological Activity

BAM (8-22) is a proenkephalin A-derived peptide that acts as a potent agonist of Mas-related G-protein-coupled receptors, specifically mouse MrgprC11 and human MrgprX1. Activation of these sensory neuron receptors engages downstream intracellular signaling pathways involved in non-histaminergic itch transmission, which stimulates sensation and induces robust scratching responses in vivo in an Mrgpr-dependent manner. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (50.73 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water 100 mg/mL
Ethanol 100 mg/mL
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

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Note: Technical data last updated: Sep 1, 2026.