CAS No. 25126-32-3

Batch: Purity:99.05
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CCK Octapeptide (Sincalide) Chemical Structure CCK Octapeptide (Sincalide) Chemical Structure
Chemical Structure
Check the CCK Octapeptide (Sincalide) product page for in-depth specifications, including solubility, stock solutions, MOA, and working concentrations.

Chemical Information

IUPAC Name (3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-1-oxo-3-(4-sulfooxyphenyl)propan-2-yl]amino]-4-oxobutanoic acid
CAS Number 25126-32-3
Molecular Formula

C49H62N10O16S3
Molecular Weight (MW) 1143.27
SMILES CSCCC(NC(=O)C(CC1=CC=C(O[S](O)(=O)=O)C=C1)NC(=O)C(N)CC(O)=O)C(=O)NCC(=O)NC(CC2=C[NH]C3=CC=CC=C23)C(=O)NC(CCSC)C(=O)NC(CC(O)=O)C(=O)NC(CC4=CC=CC=C4)C(N)=O
InChIKey IZTQOLKUZKXIRV-YRVFCXMDSA-N

Biological Activity

CCK Octapeptide (Sincalide) is an endogenous peptide hormone and cholecystokinin (CCK) receptor agonist that acts on both CCK1 and CCK2 receptors. Upon binding, CCK Octapeptide triggers intracellular calcium mobilization and activates downstream signaling cascades, including G protein-coupled receptor pathways, to stimulate digestive processes such as gallbladder contraction and pancreatic enzyme secretion, while also regulating central gastrointestinal satiety and motility. [1]

How to Prepare Stock Solution?

Concentration Volume Mass
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Solubility

Batch:
All in vitro solubility values are batch-tested experimental data (non-literature values).
Solvent Solubility & Note
DMSO 100 mg/mL (87.46 mM)
(Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO. The recommended stock concentration is 10 mM in DMSO.)
Water Insoluble
Ethanol Insoluble
FAQ
Q: Why does a DMSO stock precipitate in media/saline?
A: It is caused by unheated aqueous media (supersaturation), local solvent shock, or incorrect mixing sequence.
How to fix it?
  • Preheat media/saline to 37°C.
  • Mix rapidly (pipette/vortex) upon addition.
  • For complex mixes, always add the aqueous phase last.
  • Re-dissolve minor precipitates with a 37°C water bath and sonication (≤30 min).

Reference

[1] Crawley JN, et al. Peptides. 1994;15(4):731-55.

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Note: Technical data last updated: Sep 1, 2026.