Home Primary Antibodies Mucin 5AC Antibody [L15D9]

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Mucin 5AC Antibody [L15D9]

Catalog No.: F1564

    Application: Reactivity:

    Usage Information

    Dilution
    1:100 - 1:5000
    1:100
    Application
    IHC, IF
    Reactivity
    Mouse, Rat, Human
    Source
    Mouse Monoclonal Antibody
    Storage Buffer
    PBS, pH 7.2+50% Glycerol+0.05% BSA+0.01% NaN3
    Storage (from the date of receipt)
    -20°C (avoid freeze-thaw cycles), 2 years

    Datasheet & SDS

    Biological Description

    Specificity
    Mucin 5AC Antibody [L15D9] detects endogenous levels of total Mucin 5AC protein.
    Clone
    L15D9
    Synonym(s)
    MUC5; MUC5AC; Mucin-5AC; MUC-5AC; Gastric mucin; Major airway glycoprotein; Tracheobronchial mucin; TBM
    Background
    Mucin 5AC (MUC5AC) is a secreted, gel-forming mucin glycoprotein belonging to the mucin family, predominantly expressed by goblet cells in the respiratory, gastric, and conjunctival epithelia, where it constitutes the primary component of protective mucus gels. MUC5AC is a massive multidomain protein featuring N- and C-terminal globular regions with von Willebrand factor (VWF)-like D-domains (D1, D2, D2', D3, D4), cysteine-rich subdomains (CysD1-9), and a central proline/threonine/serine-rich (PTS) mucin domain densely O-glycosylated (>80% mass as carbohydrate) that extends into rigid rod-like structures; N-terminal D1-D3 domains mediate multimerization into tightly branched networks via disulfide bonds and homotypic interactions. MUC5AC polymerizes with MUC5B to form viscoelastic mucus layers that trap pathogens, facilitate mucociliary clearance, lubricate epithelia, and bind water for barrier hydration; its biophysical properties create stiffer, denser gels compared to MUC5B due to extensive branching. MUC5AC expression is upregulated via EGFR and IL-13/STAT6 pathways during inflammation, contributing to airway obstruction in asthma, COPD, and cystic fibrosis, where hypersecretion impairs clearance; it also promotes tumor progression in lung adenocarcinoma via ANXA2 signaling.
    References
    • https://pubmed.ncbi.nlm.nih.gov/29415129/
    • https://pubmed.ncbi.nlm.nih.gov/34548396/

    Tech Support

    Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

    Handling Instructions

    Tel: +1-832-582-8158 Ext:3
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