Home Primary Antibodies Desmoglein 1 Antibody [L24P16]

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Desmoglein 1 Antibody [L24P16]

Catalog No.: F2693

    Application: Reactivity:

    Usage Information

    Dilution
    1:300-1:1000
    1:100-1:200
    1:10-1:100
    Application
    WB, IP, IHC
    Reactivity
    Human
    Source
    Mouse Monoclonal Antibody
    Storage Buffer
    PBS, pH 7.2+50% Glycerol+0.05% BSA+0.01% NaN3
    Storage (from the date of receipt)
    -20°C (avoid freeze-thaw cycles), 2 years

    Datasheet & SDS

    Biological Description

    Specificity
    Desmoglein 1 Antibody [L24P16] detects endogenous levels of total Desmoglein 1 protein.
    Clone
    L24P16
    Synonym(s)
    Cadherin family member 4; Desmoglein-1; Desmosomal glycoprotein 1; DG1; Pemphigus foliaceus antigen; CDHF4; DG1; DSG; DSG1; EPKHE; EPKHIA; PPKS1; SPPK1
    Background
    Desmoglein 1 (DSG1) is a transmembrane glycoprotein cadherin of the desmoglein subfamily within desmosomes, predominantly expressed in the superficial granular and cornified layers of stratified epithelia, where it provides mechanical strength. DSG1 comprises a signal peptide, prodomain with RRQKR cleavage site yielding a 1000-amino acid mature protein, extracellular region with four cadherin domains (EC1-EC4) featuring Ca²⁺-binding motifs for homophilic adhesion, a transmembrane domain that drives lipid raft association via length and bulkiness, and a cytoplasmic tail with intracellular anchor (IA), proline-rich, and desmoglein-specific regions binding plakoglobin, plakophilin, and Erbin. DSG1 mediates calcium-dependent intercellular adhesion by trans-interacting EC1 domains clustered in lipid rafts, linking via plaque proteins to keratin filaments for tissue resilience under stress; its cytoplasmic tail suppresses EGFR/Erk signaling independent of adhesion, promoting keratinocyte differentiation, stratification, and barrier maturation. DSG1 TMD properties regulate desmosome assembly dynamics, plakoglobin recruitment, and cell surface stability. DSG1 autoantibodies cause pemphigus foliaceus acantholysis, mutations lead to striate palmoplantar keratoderma, and downregulation (e.g., by IL-13) impairs the esophageal barrier in eosinophilic esophagitis.
    References
    • https://pubmed.ncbi.nlm.nih.gov/23524961/
    • https://pubmed.ncbi.nlm.nih.gov/39504468/

    Tech Support

    Answers to questions you may have can be found in the inhibitor handling instructions. Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.

    Handling Instructions

    Tel: +1-832-582-8158 Ext:3
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