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How to Cite 1. For In-Text Citation (Materials & Methods): 2. For Key Resources Table: |
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Technical Data
| Formula | ||||
| Molecular Weight | CAS No. | 949109-75-5 | ||
| Solubility (25°C)* | In vitro | 4-Methylpyridine | 28 mg/mL | |
| DMSO | Insoluble | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Phytosterols, also called plant sterols or stanol esters, are specialized compounds found in plants that are structurally similar to cholesterol found in humans. |
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| In vitro | Plant sterols or phytosterols are structurally similar to cholesterol and exist in several forms in plants, including β-sitosterol, campesterol, stigmasterol and cycloartenol. This compound can protect cells from damage by reactive oxygen species. It can promote cell apoptosis. The incorporation of this chemical into lipid rafts, altering their structure, may result in beneficial changes in signal transduction[1]. |
| In vivo | Phytosterol and stanol (or phytosterols) consumption reduces intestinal cholesterol absorption, leading to decreased blood LDL-cholesterol levels and lowered cardiovascular disease risk. Recent studies suggest that this compound inhibits the production of carcinogens, cancer-cell growth, invasion and metastasis, and promote apoptosis of cancerous cells. It occurs naturally in plants either esterified with fatty acids in the cell membranes or in free form within the cells. After ingestion, it is emulsified by bile salts secreted into the small intestine to form micelles for digestion. After micelle formation, the esterified form is hydrolyzed to free phytosterols probably by cholesterol esterase and pancreatic lipase enzymes. Free phytosterols are then absorbed into enterocytes. In the enterocytes, these compounds become esterified to fatty acids by acyl-CoA cholesterol acyltransferases, and combined with cholesterol, triacylglycerol and apolipoproteins to form chylomicrons. The chylomicrons are secreted into the lymph and then transferred to the bloodstream, where they are transformed to chylomicron remnants after the uptake of triacylglycerol by cells and transported to the liver. In the liver, they may either be used for synthesis of bile salts or be incorporated into very low-density lipoproteins and be secreted into the blood, from where they are converted to low-density lipoproteins and presented to cells for uptake. In the tissues, they are incorporated into the cell membranes and have been found to be highly concentrated in the lungs, adrenal cortex, intestinal epithelia and ovaries[1]. |
Protocol (from reference)
References
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
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