Clindamycin

Catalog No.S2830 Batch:S283050

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Technical Data

Formula

C18H33ClN2O5S
Molecular Weight 424.98 CAS No. 18323-44-9
Solubility (25°C)* In vitro DMSO 85 mg/mL (200.0 mM)
Ethanol 85 mg/mL (200.0 mM)
Water Insoluble
In vivo (Add solvents to the product individually and in order)
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O

Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.

 1.000mg/ml (2.35mM) Taking the 1 mL working solution as an example, add 50 μL of 20 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Clindamycin inhibits protein synthesis by acting on the 50S ribosomal, used for the treatment of bacterial infections.
In vitro Clindamycin is a semisynthetic analogue of lincomycin. It primarily inhibits the initiation of peptide chain synthesis by deregulating enzyme-catalyzed initiation of peptide bounds. This compound appears to have a modest effect on protein synthesis by certain mammalian cells. [1] It is active against most gram-positive aerobic bacteria. This antibiotic is about eight times more active than lincomycin against Staphylococcus aureus and Streptococcus pneumonia. It is four times more active than erythromycin against S. aureus and is active even against strains that are resistant to erythromycin, penicillin, and methicillin. It is active against gram-positive anaerobes. This agent highly activates against Bacteroides specie. [2] It also alters the bacterial surface in such a way that phagocytosis and intracellular killing of the bacteria is greatly facilitated. This drug potentiates opsonization and phagocytosis. [4]
In vivo Clindamycin (50mg/kg daily administrated by intramuscular) increases the survival rate of monkeys infected with penicillin-resistant S. aureu to 87.5% (7/8). [5] This compound (40 mg/kg administrated three times daily) protects 87.5% (7/8) of rabbits from anaerobic pulmonary infections induced by transtracheal inoculation of a mixture of B. fragillis, Streptococcus morbillorm, Fusobacterium nucleatum and Eubacterium lentum. [6] This chemical (400 mg/kg treated by mixed in the diet) increases survival rate of mice infected with the Toxoplasma gondii to 100%, while all animals die in untreated group. [7]

Protocol (from reference)

References

  • https://pubmed.ncbi.nlm.nih.gov/1262717/
  • https://pubmed.ncbi.nlm.nih.gov/6818656/
  • https://pubmed.ncbi.nlm.nih.gov/4994902/
  • https://pubmed.ncbi.nlm.nih.gov/7014632/
  • https://pubmed.ncbi.nlm.nih.gov/4386950/
  • https://pubmed.ncbi.nlm.nih.gov/7075325/
  • https://pubmed.ncbi.nlm.nih.gov/4684885/

Selleck's Clindamycin Has Been Cited by 2 Publications

Repurposed clindamycin suppresses pyroptosis in tumor-associated macrophages through Inhibition of caspase-1 [ J Exp Clin Cancer Res, 2025, 44(1):225] PubMed: 40759978
3D collagen high-throughput screen identifies drugs that induce epithelial polarity and enhance chemotherapy response in colorectal cancer [ Commun Biol, 2025, 8(1):1261] PubMed: 40847193

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.