Scopolamine (LSM-4015) HBr

Catalog No.S2508 Batch:S250802

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Technical Data

Formula

C17H21NO4.HBr

Molecular Weight 384.26 CAS No. 114-49-8
Solubility (25°C)* In vitro DMSO 76 mg/mL (197.78 mM)
Water 76 mg/mL (197.78 mM)
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Scopolamine HBr (LSM-4015,NSC 61806,(-)-Scopolamine hydrobromide, Hyoscine hydrobromide, Scopine hydrobromide) is a competitive muscarinic acetylcholine receptor antagonist with an IC50 of 55.3 nM.
Targets
mAChR [1]
55.3 nM

Protocol (from reference)

Selleck's Scopolamine (LSM-4015) HBr has been cited by 7 publications

SREBP1 deficiency diminishes glutamate-mediated HT22 cell damage and hippocampal neuronal pyroptosis induced by status epilepticus [ Heliyon, 2024, 10(1):e23945] PubMed: 38205297
Scopolamine causes delirium-like brain network dysfunction and reversible cognitive impairment without neuronal loss [ Zool Res, 2023, 44(4):712-724] PubMed: 37313848
Scopolamine causes delirium-like brain network dysfunction and reversible cognitive impairment without neuronal loss [ Zool Res, 2023, 44(4):712-724] PubMed: 37313848
Phosphorylation of PRAS40 contributes to the activation of the PI3K/AKT/mTOR signaling pathway and the inhibition of autophagy following status epilepticus in rats [ Exp Ther Med, 2020, 20(4):3625-3632] PubMed: 32855714
Conformational Complexity and Dynamics in a Muscarinic Receptor Revealed by NMR Spectroscopy. [ Mol Cell, 2019, 75(1):53-65] PubMed: 31103421
WDR45 contributes to neurodegeneration through regulation of ER homeostasis and neuronal death. [ Autophagy, 2019, 10.1080/15548627.2019.1630224] PubMed: 31204559
Accumulation of 8,9-unsaturated sterols drives oligodendrocyte formation and remyelination [Hubler Z, et al. Nature, 2018, 560(7718):372-376] PubMed: 30046109

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.