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Technical Data
| Formula | C21H24ClN7O |
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| Molecular Weight | 425.91 | CAS No. | 1383716-33-3 | |
| Solubility (25°C)* | In vitro | DMSO | 85 mg/mL (199.57 mM) | |
| Ethanol | 85 mg/mL (199.57 mM) | |||
| Water | Insoluble | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Vps34-IN1 is a potent and highly selective Vps34 inhibitor with IC50 of 25 nM invitro,which does not significantly inhibit the isoforms of class I as well as class II PI3Ks. Vps34-IN1 modulates autophagy. | ||
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| In vitro | Administration of VPS34-IN1 to cells induces a rapid dose-dependent dispersal of a specific PtdIns(3)P-binding probe from endosome membranes, within 1min, without affecting the ability of class I PI3K to regulate Akt. It can also induce a rapid ~50-60% loss of SGK3 phosphorylation within 1min. VPS34-IN1 has no inhibition to the SGK2 isoform that does not possess a PtdIns(3)P-binding PX domain[1]. |
Protocol (from reference)
Customer Product Validation
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Data from [Data independently produced by , , Oncotarget, 2017, 8(24):38099-38112]
Selleck's VPS34-IN1 has been cited by 29 publications
| An evolutionary-conserved VPS34-PIKfyve-TRPML1-Myosin II axis regulates the speed of amoeboid cell migration [ bioRxiv, 2024, 10.1101/2024.01.22.575998] | PubMed: none |
| Class 3 PI3K coactivates the circadian clock to promote rhythmic de novo purine synthesis [ Nat Cell Biol, 2023, 25(7):975-988] | PubMed: 37414850 |
| S-acylation of p62 promotes p62 droplet recruitment into autophagosomes in mammalian autophagy [ Mol Cell, 2023, 83(19):3485-3501.e11] | PubMed: 37802024 |
| Dihydroartemisinin-induced ferroptosis in acute myeloid leukemia: links to iron metabolism and metallothionein [ Cell Death Discov, 2023, 9(1):97] | PubMed: 36928207 |
| MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells [ Cancer Cell, 2022, S1535-6108(21)00662-0] | PubMed: 35051357 |
| Inhibition of Vps34 and p110δ PI3K Impairs Migration, Invasion and Three-Dimensional Spheroid Growth in Breast Cancer Cells [ Int J Mol Sci, 2022, 23-169008] | PubMed: 36012280 |
| Bortezomib abrogates temozolomide-induced autophagic flux through an ATG5 dependent pathway [ Front Cell Dev Biol, 2022, 10:1022191] | PubMed: 36619857 |
| Inhibition of lipid kinase PIKfyve reveals a role for phosphatase Inpp4b in the regulation of PI(3)P-mediated lysosome dynamics through VPS34 activity [ J Biol Chem, 2022, 298(8):102187] | PubMed: 35760104 |
| ALFY localizes to early endosomes and cellular protrusions to facilitate directional cell migration [ J Cell Sci, 2022, jcs.259138] | PubMed: 35099014 |
| Dynamic glucose uptake, storage, and release by human microvascular endothelial cells [ Mol Biol Cell, 2022, 33(12):ar106] | PubMed: 35921166 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.