Vitexin

Catalog No.S9192 Batch:S919201

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Technical Data

Formula

C21H20O10
Molecular Weight 432.38 CAS No. 3681-93-4
Solubility (25°C)* In vitro DMSO 47 mg/mL (108.7 mM)
 
 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Vitexin (Apigenin-8-C-glucoside), an naturally occuring apigenin flavone glycoside, acts as a platelet aggregation and alpha-glucosidase inhibitor and shows antineoplastic activity.
Targets
HIF-1α [4] SIRT6 [3] SIRT6 [3]
In vitro Vitexin promotes cell viability, inhibits apoptosis, and decreases inflammatory cytokines. These protective effects are related to the regulation of ER stress by vitexin in chondrocytes[2].
In vivo Vitexin ameliorates sexual dysfunction and fertility impairments in male diabetic mice possibly by modulating the hypothalamus-pituitary-gonadal axis[1].

Protocol (from reference)

Cell Assay:

[2]
  • Cell lines

    Chondrocytes

  • Concentrations

    0-100 μM

  • Incubation Time

    24 h

  • Method

    Chondrocytes (2 × 105 cells) were planted in a 96-well plate and treated with various doses of vitexin, with or without IL-1β (10 ng/mL), for 1 day according to the requirements of the experiment. All of the chondrocytes were incubated for 2 h with cholecystokinin octapeptide (CCK-8) (10 µL) and the absorbance of the reaction at 450 nm was then quantified using a micro-plate reader.
Animal Study:

[1]
  • Animal Models

    adult male mice (25–30 g)

  • Dosages

    10, 20 and 40 mg/kg

  • Administration

    oral

Selleck's Vitexin has been cited by 4 publications

Vitexin protects melanocytes from oxidative stress via activating MAPK-Nrf2/ARE pathway [ Immunopharmacol Immunotoxicol, 2020, 42(6):594-603] PubMed: 33045867
Vitexin protects dopaminergic neurons in MPTP-induced Parkinson's disease through PI3K/Akt signaling pathway [ Drug Des Devel Ther, 2018, 12:565-573] PubMed: 29588573
Vitexin induces G2/M‑phase arrest and apoptosis via Akt/mTOR signaling pathway in human glioblastoma cells. [ Mol Med Rep, 2018, 17(3):4599-4604] PubMed: 29328424
Vitexin suppresses autophagy to induce apoptosis in hepatocellular carcinoma via activation of the JNK signaling pathway. [ Oncotarget, 2016, 7(51):84520-84532] PubMed: 27588401

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.