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How to Cite 1. For In-Text Citation (Materials & Methods): 2. For Key Resources Table: |
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Technical Data
| Formula | C7H19N3 |
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| Molecular Weight | 145.25 | CAS No. | 124-20-9 | |
| Solubility (25°C)* | In vitro | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Spermidine is a natural polyamine that stimulates cytoprotective macroautophagy/autophagy. | |||||
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| In vitro | Spermidine and spermine significantly increases the viability and proliferation of SKOV-3 cells in a time-dependent manner, and decreases the apoptotic effect of Difluoromethylornithine (DFMO) in SKOV-3 cells. |
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| In vivo | Spermidine, a selective activator of TC45, rescues exacerbated phenotype of Hematopoietic stem and progenitor cells (HSPCs) in IFN‐γ‐treated Hemgn-/- mice. |
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| Density | 1g/ml | |||||
Protocol (from reference)
| Cell Assay: |
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References
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Selleck's Spermidine Has Been Cited by 15 Publications
| Mesenchymal stem cell extracellular vesicles ameliorate radiation-caused dry mouth via modulating immune balance and cell metabolism [ Stem Cell Research & Therapy, October 24, 2025, 579] | PubMed: nan |
| Mesenchymal stem cell extracellular vesicles ameliorate radiation-caused dry mouth via modulating immune balance and cell metabolism [ Stem Cell Research & Therapy, October 24 2025, 579] | PubMed: 41272785 |
| Hemgn Protects Hematopoietic Stem and Progenitor Cells Against Transplantation Stress Through Negatively Regulating IFN-γ Signaling [ Advanced Science, February 15 2022, e2103838] | PubMed: 34923767 |
| Hemgn Protects Hematopoietic Stem and Progenitor Cells Against Transplantation Stress Through Negatively Regulating IFN‐γ Signaling [ Advanced Science, December 19, 2021, e2103838] | PubMed: 34923767 |
| Mesenchymal stem cell extracellular vesicles ameliorate radiation-caused dry mouth via modulating immune balance and cell metabolism [ Stem Cell Res Ther, 2025, 16(1):579] | PubMed: 41272785 |
| Mesenchymal stem cell extracellular vesicles ameliorate radiation-caused dry mouth via modulating immune balance and cell metabolism [ Stem Cell Research & Therapy, 2024, 72] | PubMed: 41272785 |
| Metabolic support by macrophages sustains colonic epithelial homeostasis [ Cell Metab, 2023, S1550-4131(23)00341-8] | PubMed: 37804836 |
| Rebalance of the Polyamine Metabolism Suppresses Oxidative Stress and Delays Senescence in Nucleus Pulposus Cells [ Oxid Med Cell Longev, 2022, 2022:8033353] | PubMed: 35178160 |
| Rebalance of the Polyamine Metabolism Suppresses Oxidative Stress and Delays Senescence in Nucleus Pulposus Cells [ Oxidative Medicine and Cellular Longevity, 2022, 8033353] | PubMed: 35178160 |
| Screening Health-Promoting Compounds for Their Capacity to Induce the Activity of FOXO3 [ J Gerontol A Biol Sci Med Sci, 2022, 77-8:1485-1493] | PubMed: 34508571 |
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
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