Sodium Houttuyfonate

Catalog No.S3801 Batch:S380102

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Technical Data

Formula

C14H27O5S.Na
Molecular Weight 330.42 CAS No. 1847-58-1
Solubility (25°C)* In vitro DMSO 2 mg/mL (6.05 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description Sodium Houttuyfonate, the active compound of the Houttuynia plant, is mainly used for treating purulent skin infections, respiratory tract infections, including pneumonia in elderly patients, and chronic bronchitis.
In vitro Treatment with sodium houttuyfonate results in an increase in the expression of c-Fos protein in macrophages, while the phosphorylation level of extracellular signal-related kinase 1/2 (ERK1/2) is not affected by the treatment[2].
In vivo Sodium houttuyfonate has been shown to protect against cationized bovine serum albumin (C-BSA)-induced glomerulonephritis in BALB/C mice through the suppression of the urine protein, morphological character and monocyte chemotactic protein 1 (MCP-1). In addition, sodium houttuyfonate treatment has been shown to induce a respiratory burst and to increase the concentration of free calcium in macrophages, as well as increase IL-2 within T-cells. Sodium houttuyfonate in the serum, stomach and intestine can be detected immediately by GC at 0.5 h. The concentration of sodium houttuyfonate in the stomach gradually increases from 0.5–2 h, but is drastically reduced at 4 h. Furthermore, the concentration in the serum and intestine at 1–4 h decreases in a time-dependent manner, indicating that sodium houttuyfonate can be quickly absorbed into the circulatory system and intestine and might be quickly distributed to other organs, such as trachea, lung, brain, heart and kidney[2].

Protocol (from reference)

Cell Assay:[1]
  • Cell lines

    synovial cells

  • Concentrations

    25, 50, 100, 200 μg/ml

  • Incubation Time

    seven days

  • Method

    The primary cells are equally divided into five groups as follows: the control group (group 1), cells treated with 25 μg/ml sodium houttuyfonate (group 2), 50 μg/ml sodium houttuyfonate (group 3), 100 μg/ml sodium houttuyfonate (group 4) and 200 μg/ml sodium houttuyfonate (group 5). Group 1 is administered an equivalent amount of normal saline (NS), whilst groups 2 to 5 are treated with corresponding amounts of sodium houttuyfonate. NS and sodium houttuyfonate are administered daily for 7 days by transfer pipette. Following the final administration, the five groups of synovial cells are measured using an MTT assay for analysis of the growth inhibitory rate of SH on synovial proliferation.

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.