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How to Cite 1. For In-Text Citation (Materials & Methods): 2. For Key Resources Table: |
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Technical Data
| Formula | C25H18Cl3FN2O4 |
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| Molecular Weight | 535.78 | CAS No. | 1898206-17-1 | |
| Solubility (25°C)* | In vitro | |||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Biological Activity
| Description | Safusidenib (AB-291; DS-1001) is an orally bioavailable, selective inhibitor of mutant IDH1. It demonstrates potent inhibition against mutant IDH1 while showing minimal activity against the wild-type enzyme. This compound exhibits antitumor effects in chondrosarcoma models. In vitro assays without preincubation, it inhibits IDH1R132H and IDH1R132C with IC50 values of 15 nM and 130 nM, respectively. |
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| In vivo | Safusidenib (DS-1001b) has antineoplastic activity in JJ012 xenografts. Continuous administration of this compound (mixed with sterilized pellet food and fed continuously for 6 weeks) impairs tumor growth in xenograft mice. |
Protocol (from reference)
References
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