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Formula | C26H38N2O9 |
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Molecular Weight | 522.59 | CAS No. | 442201-24-3 | |
Solubility (25°C)* | In vitro | DMSO | 100 mg/mL (191.35 mM) | |
Ethanol | 25 mg/mL (47.83 mM) | |||
Water | Insoluble | |||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | Remogliflozin etabonate (GSK189075) is an orally active, selective and low-affinity inhibitor of sodium glucose cotransporter (SGLT2) with Ki of 1950 nM, 2140 nM, 43100 nM, 8570 nM for hSGLT2, rSGLT2, hSGLT1, rSGLT1, respectively. Remogliflozin etabonate exhibits antidiabetic efficacy in rodent models. | ||||||||
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In vitro | Remogliflozin etabonate, a prodrug based on benzylpyrazole glucoside, is metabolized to its active form, remogliflozin, which is a potent and highly selective SGLT2 inhibitor by examining COS-7 cells transiently expressing either high-affinity sodium glucose cotransporter (SGLT1) or SGLT2.[1] |
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In vivo | Treatment with remogliflozin etabonate exhibits antidiabetic efficacy in several rodent models, suggesting that remogliflozin etabonate may be a new and useful drug for the treatment of diabetes.[1] |
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
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