Phenibut

Catalog No.S4892 Batch:S489202

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Technical Data

Formula

C10H13NO2
Molecular Weight 179.22 CAS No. 1078-21-3
Solubility (25°C)* In vitro DMSO 36 mg/mL (200.87 mM)
Water 36 mg/mL (200.87 mM)
Ethanol 36 mg/mL (200.87 mM)
In vivo (Add solvents to the product individually and in order)
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O

Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.

 1.8mg/ml (10.04mM) Taking the 1 mL working solution as an example, add 50 μL of 36 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
Clear solution
5% DMSO 95% Corn oil

Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.

 0.26mg/ml (1.45mM) Taking the 1 mL working solution as an example, add 50 μL of 5.2 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Phenibut (Aminophenylbutyric acid, Fenibut, Phenigam, Phenybut, PhGABA, β-Phenyl-γ-aminobutyric acid, β-Phenyl-GABA), a GABA analogue, is a central nervous system depressant with anxiolytic and sedative effects.
Targets
GABA receptor [1]
In vitro

Phenibut has anxiolytic and nootropic (cognition enhancing) effects. It acts as a GABA-mimetic, primarily at GABAB and, to some extent, at GABAA receptors. This compound also stimulates dopamine receptors and antagonizes β-phenethylamine (PEA), a putative endogenous anxiogenic[1].
In vivo

At doses that do not affect motor activity (e.g., 20 mg/kg i.p.), Phenibut inhibits food conditioned reflexes in mice. At doses higher than 70 mg/kg i.p., this compound reduces motor and exploratory activities, rearings, muscle tone, coordination and body temperature. Following intravenous administration to either rabbits or rats it is not metabolized. This chemical is largely excreted in the urine. At 15, 30, 60, or 90 min following i.v. administration it is found in liver, kidneys, and urine. Traces of the compound are found in blood and brain. 180 min after i.v. injection only traces of the drug are found in all tissues studied. In cats and dogs, it, after a single dose of 50 mg/kg i.v., is excreted in the urine unchanged. The acute toxicity of this substance is low. Its LD50 is 900 mg/kg i.p. in mice and 700 mg/kg i.p. in rats[1]. Administration of this agent leads to decreases in horizontal movement activity and some elements of investigative behavior in rabbits in the open field, along with decreases in the reactivity of the animals to emotionally significant stimuli[2].

Protocol (from reference)

Animal Study:

[2]
  • Animal Models

    Chinchilla rabbits

  • Dosages

    40 mg/kg

  • Administration

    s.c.

References

  • https://pubmed.ncbi.nlm.nih.gov/11830761/
  • https://pubmed.ncbi.nlm.nih.gov/18607733/

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.