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Technical Data
| Formula | C10H13NO2 |
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| Molecular Weight | 179.22 | CAS No. | 1078-21-3 | |
| Solubility (25°C)* | In vitro | DMSO | 35 mg/mL (195.29 mM) | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
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Preparing Stock Solutions
Biological Activity
| Description | Phenibut (Aminophenylbutyric acid, Fenibut, Phenigam, Phenybut, PhGABA, β-Phenyl-γ-aminobutyric acid, β-Phenyl-GABA), a GABA analogue, is a central nervous system depressant with anxiolytic and sedative effects. | |
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| Targets |
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| In vitro | Phenibut has anxiolytic and nootropic (cognition enhancing) effects. It acts as a GABA-mimetic, primarily at GABAB and, to some extent, at GABAA receptors. It also stimulates dopamine receptors and antagonizes β-phenethylamine (PEA), a putative endogenous anxiogenic[1]. | |
| In vivo | At doses that do not affect motor activity (e.g., 20 mg/kg i.p.), Phenibut inhibits food conditioned reflexes in mice. At doses higher than 70 mg/kg i.p., Phenibut reduces motor and exploratory activities, rearings, muscle tone, coordination and body temperature. Phenibut potentiates central effects of the anesthetics: ether, chloral hydrate, and barbiturates. Following intravenous administration to either rabbits or rats phenibut is not metabolized. Phenibut is largely excreted in the urine. At 15, 30, 60, or 90 min following i.v. administration Phenibut is found in liver, kidneys, and urine. Traces of phenibut are found in blood and brain. 180 min after i.v. injection only traces of the drug are found in all tissues studied. In cats and dogs, phenibut, after a single dose of 50 mg/kg i.v., is excreted in the urine unchanged. The acute toxicity of phenibut is low. Its LD50 is 900 mg/kg i.p. in mice and 700 mg/kg i.p. in rats[1]. Phenibut administration leads to decreases in horizontal movement activity and some elements of investigative behavior in rabbits in the open field, along with decreases in the reactivity of the animals to emotionally significant stimuli[2]. |
Protocol (from reference)
| Animal Study: |
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References
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RETURN POLICY
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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
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