NG25

Catalog No.S8868 Batch:S886802

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Technical Data

Formula

C29H30F3N5O2
Molecular Weight 537.58 CAS No. 1315355-93-1
Solubility (25°C)* In vitro DMSO 80 mg/mL (148.81 mM)
Ethanol 2 mg/mL (3.72 mM)
Water Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

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Biological Activity

Description NG25 is a novel inhibitor of TAK1 with enzymatic IC50s of 149 and 21.7 nM for TAK1 and MAP4K2 respectively.
Targets
TAK1 [1] MAP4K2 [1]
In vitro

NG25 can inhibit phosphorylation of proteins predicted to be downstream of TAK1 and MAP4K2 such as IKK, p38 and JNK at concentrations of less than 100 nM[1].

Protocol (from reference)

Cell Assay:

[2]
  • Cell lines

    AM-1 cells

  • Concentrations

    100 nM

  • Incubation Time

    1 h

  • Method

    For the inhibition of TAK1 expression, cells were preincubated in DMEM with 100 nM NG25 at 37 °C, 5% CO2 for 1 h.
Animal Study:

[2]
  • Animal Models

    Male Swiss albino mice

  • Dosages

    1 mg/kg

  • Administration

    i.v. or o.g.

Selleck's NG25 has been cited by 3 publications

TXNIP in liver sinusoidal endothelial cells ameliorates alcohol-associated liver disease via nitric oxide production [ Int J Biol Sci, 2024, 20(2):606-620] PubMed: 38169654
Co-ordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC [ Biochem J, 2022, 479(20):2195-2216] PubMed: 36098982
αTAT1-induced tubulin acetylation promotes ameloblastoma migration and invasion [ Lab Invest, 2021, 10.1038/s41374-021-00671-w] PubMed: 34508164

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.