Nebivolol

Catalog No.S5739 Batch:S573901

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Technical Data

Formula

C22H25F2NO4
Molecular Weight 405.43 CAS No. 118457-14-0
Solubility (25°C)* In vitro DMSO 88 mg/mL (217.05 mM)
 
 
In vivo (Add solvents to the product individually and in order)
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Clear solution
5%DMSO 40%PEG300 5%Tween80 50%ddH2O

Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.

 4.4mg/ml (10.85mM) Taking the 1 mL working solution as an example, add 50 μL of 88 mg/ml clarified DMSO stock solution to 400 μL of PEG300, mix evenly to clarify it; add 50 μL of Tween80 to the above system, mix evenly to clarify; then continue to add 500 μL of ddH2O to adjust the volume to 1 mL. The mixed solution should be used immediately for optimal results. 
Clear solution
5% DMSO 95% Corn oil

Validated by Selleck labs. Should you need adjustments to this formulation, contact our sales team for custom testing.

 4.4mg/ml (10.85mM) Taking the 1 mL working solution as an example, add 50 μL of 88 mg/ml clear DMSO stock solution to 950 μL of corn oil and mix evenly. The mixed solution should be used immediately for optimal results. 
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Nebivolol (Bystolic,R 065824) is a β1 receptor blocker with nitric oxide-potentiating vasodilatory effect used in treatment of hypertension and also for left ventricular failure.

Protocol (from reference)

Selleck's Nebivolol Has Been Cited by 13 Publications

Therapeutic Effects of Combination of Nebivolol and Donepezil: Targeting Multifactorial Mechanisms in ALS [ Neurotherapeutics, October 2023, 1779-1795] PubMed: 37782409
Stress and Obesity Signaling Converge on CREB Phosphorylation to Promote Pancreatic Cancer [ Molecular Cancer Research, March 3, 2025, 236-249] PubMed: 39642318
Nebivolol Inhibits Hepatocellular Carcinoma via RHOQ and Enhances the Efficacy of Lenvatinib [ International Journal of Biological Sciences, March 25, 2026, 3617-3634]
Screening of GPCR drugs for repurposing in breast cancer [ Frontiers in Pharmacology, December 6, 2022, 1049640] PubMed: 36561339
Adrenergic Blockade by Nebivolol to Suppress Oral Squamous Cell Carcinoma Growth via Endoplasmic Reticulum Stress and Mitochondria Dysfunction [ Frontiers in Pharmacology, August 12, 2021, 691998] PubMed: 34456721
Integrated screening for small molecules interfering with PKM2: a drug repurposing strategy against glioblastoma [ J Transl Med, 2025, 23(1):1388] PubMed: 41361767
Masitinib Inhibits Hepatitis A Virus Replication [ Int J Mol Sci, 2023, 24(11)9708] PubMed: 37298659
Masitinib Inhibits Hepatitis A Virus Replication [ International Journal of Molecular Sciences, 2023, 9708] PubMed: 37298659
Screening of GPCR drugs for repurposing in breast cancer [ Frontiers in Pharmacology, 2022, 1049640] PubMed: 36561339
Screening of GPCR drugs for repurposing in breast cancer [ Front Pharmacol, 2022, 13:1049640] PubMed: 36561339

RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.

SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.