Toll Free: (877) 796-6397 -- USA and Canada only -- |
Fax: +1-832-582-8590 Orders: +1-832-582-8158 |
Tech Support: +1-832-582-8158 Ext:3 Please provide your Order Number in the email. |
Formula | C15H22N2O4 |
||||||
Molecular Weight | 294.35 | CAS No. | 1418033-25-6 | ||||
Solubility (25°C)* | In vitro | DMSO | 7 mg/mL (23.78 mM) | ||||
Water | Insoluble | ||||||
Ethanol | Insoluble | ||||||
In vivo (Add solvents to the product individually and in order) |
|
||||||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. * Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.) |
Description | LMK-235 is a selective inhibitor of HDAC4 and HDAC5 with IC50 of 11.9 nM and 4.2 nM, respectively. | ||||
---|---|---|---|---|---|
Targets |
|
||||
In vitro | LMK-235 causes HDAC inhibition with IC50 of <1 μM in human cancer cell lines with different sensitivity towards cisplatin. In breast cancer cell line MDA-MB-231, tongue cancer cell line Cal27, and esophagus cell line Kyse510 cell line, LMK-235 displays a high cytotoxicity, and markedly enhances the cytotoxicity of cisplatin. [1] In addition, LMK-235 also shows nanomolar activity against multiple malaria parasite life cycle stages. [2] |
||||
In vivo | LMK-235 is a selective inhibitor of HDAC4. |
Kinase Assay: |
|
---|---|
Cell Assay: |
|
Animal Study: |
|
|
Data from [Data independently produced by , , Clin Epigenetics, 2018, 10(1):120]
Data from [Data independently produced by , , Oncotarget, 2016, 7(39):63829-63838]
Data from [Data independently produced by , , Oncotarget, 2016, 7(25):37966-37978]
Data from [Data independently produced by , , J Biol Chem, 2016, 291(14):7386-95.]
Protective effect of HDACIs in improves survival and organ injury after CLP-induced sepsis [ Surg Open Sci, 2023, 12:35-42] | PubMed: 36936452 |
Kinase signalling in excitatory neurons regulates sleep quantity and depth [ Nature, 2022, 612(7940):512-518] | PubMed: 36477539 |
HDAC5-mediated Smad7 silencing through MEF2A is critical for fibroblast activation and hypertrophic scar formation [ Int J Biol Sci, 2022, 18(15):5724-5739] | PubMed: 36263180 |
Yeast beta-glucan mediates histone deacetylase 5-induced angiogenesis in vascular endothelial cells [ Int J Biol Macromol, 2022, 211:556-567] | PubMed: 35569678 |
Leveraging patient derived models of FGFR2 fusion positive intrahepatic cholangiocarcinoma to identify synergistic therapies [ NPJ Precis Oncol, 2022, 6(1):75] | PubMed: 36274097 |
Repression of the PRELP gene is relieved by histone deacetylase inhibitors through acetylation of histone H2B lysine 5 in bladder cancer [ Clin Epigenetics, 2022, 14(1):147] | PubMed: 36371227 |
HDAC5-Mediated Acetylation of p100 Suppresses Its Processing [ Int Dent J, 2022, S0020-6539(22)00199-X] | PubMed: 36156247 |
CaMKII inhibition protects against hyperthyroid arrhythmias and adverse myocardial remodeling [ Biochem Biophys Res Commun, 2022, 615:136-142] | PubMed: 35617800 |
NADPH levels affect cellular epigenetic state by inhibiting HDAC3-Ncor complex [ Nat Metab, 2021, 3(1):75-89] | PubMed: 33462516 |
Quantitative control of noise in mammalian gene expression by dynamic histone regulation [ Elife, 2021, 10e65654] | PubMed: 34379055 |
RETURN POLICY
Selleck Chemical’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.
NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.