K02288

Catalog No.S7359 Batch:S735902

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Technical Data

Formula

C20H20N2O4

Molecular Weight 352.38 CAS No. 1431985-92-0
Solubility (25°C)* In vitro DMSO 70 mg/mL (198.64 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description K02288 is a potent, and selective type I BMP receptor inhibitor with IC50 of 1.1, 1.8, 6.4 nM for ALK2, ALK1 and ALK6, showing weaker inhibition on other ALKs (3, 4, 5) and ActRIIA.
Targets
ALK2 [1]
(Cell-free assay)
ALK1 [1]
(Cell-free assay)
ALK6 [1]
(Cell-free assay)
ALK3 [1]
(Cell-free assay)
1.1 nM 1.8 nM 6.4 nM 34.4 nM
In vitro K02288 dose-dependently inhibits BMP4- and BMP6- induced Smad1/5/8 phosphorylation in C2C12 cells without affecting TGF-β-BMP signaling. [1]
In vivo In Zebrafish Embryos, K02288 induces a dorsalized phenotype in a dose dependent manner without effect om intersomitic vessel (ISV) formation. [1]
Features A chemical probe for BMP signaling in cells.

Protocol (from reference)

Animal Study:

[1]

  • Animal Models

    Zebrafish Embryos

  • Dosages

    ~10 µM

  • Administration

    --

Customer Product Validation

, , Cancer Invest, 2017, 35(9):601-609

Selleck's K02288 has been cited by 23 publications

Defects of the spliceosomal gene SNRPB affect osteo- and chondro-differentiation [ FEBS J, 2024, 291(2):272-291] PubMed: 37584444
Inhibition of BMP signaling pathway induced senescence and calcification in anaplastic meningioma [ J Neurooncol, 2024, 10.1007/s11060-024-04625-2] PubMed: 38446374
BMP9-ID1 Signaling Activates HIF-1α and VEGFA Expression to Promote Tumor Angiogenesis in Hepatocellular Carcinoma [ Int J Mol Sci, 2022, 23(3)1475] PubMed: 35163396
Low-Dose-Rate Radiation-Induced Secretion of TGF-β3 Together with an Activator in Small Extracellular Vesicles Modifies Low-Dose Hyper-Radiosensitivity through ALK1 Binding [ Int J Mol Sci, 2022, 23(15)8147] PubMed: 35897723
Electrochemically induced in vitro focal hypoxia in human neurons [ Front Cell Dev Biol, 2022, 10:968341] PubMed: 36247014
Establishment and characterization of immortalized sweat gland myoepithelial cells [ Sci Rep, 2022, 12(1):7] PubMed: 34997030
Clonal hematopoiesis with JAK2V617F promotes pulmonary hypertension with ALK1 upregulation in lung neutrophils [ Nat Commun, 2021, 12(1):6177] PubMed: 34702814
BMP9-ID1 signaling promotes EpCAM-positive cancer stem cell properties in hepatocellular carcinoma [ Mol Oncol, 2021, 10.1002/1878-0261.12963] PubMed: 33834612
Hemodynamic Forces Regulate Cardiac Regeneration-Responsive Enhancer Activity during Ventricle Regeneration [ Int J Mol Sci, 2021, 22(8)3945] PubMed: 33920448
GATA3 Mediates a Fast, Irreversible Commitment to BMP4-Driven Differentiation in Human Embryonic Stem Cells. [ Cell Stem Cell, 2020, 7;26(5):693-706] PubMed: 32302522

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.