Emricasan (IDN-6556)

Catalog No.S7775 Batch:S777507

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Technical Data

Formula

C26H27F4N3O7
Molecular Weight 569.50 CAS No. 254750-02-2
Solubility (25°C)* In vitro DMSO 100 mg/mL (175.59 mM)
Ethanol 25 mg/mL (43.89 mM)
Water Insoluble
In vivo (Add solvents to the product individually and in order)
Homogeneous suspension
CMC-NA
≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
* Room temperature shipping (Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Biological Activity

Description Emricasan (IDN-6556, PF 03491390, PF-03491390) is a potent irreversible pan-caspase inhibitor and also functions as an inhibitor of Zika virus infection.
Targets
caspase [1]
In vitro Emricasan (IDN-6556), also called PF-03491390, is an inhibitor of activated caspases with sub- to nanomolar activity in vitro. It shows neuroprotective activity for hNPCs but does not suppress ZIKV replication[2].
In vivo In the murine NASH model, stellate cell activation and hepatic fibrogenesis are attenuated by administration of Emricasan (IDN-6556), a pan-caspase inhibitor[1]. It decreases liver injury but not metabolic derangement in NASH and also ameliorates inflammation. This compound is currently being evaluated in phase 2 clinical trials for the reduction of hepatic injury and liver fibrosis caused by chronic HCV infection[2].

Protocol (from reference)

Cell Assay:[2]
  • Cell lines

    Astrocytes

  • Concentrations

    9 μM

  • Incubation Time

    1 h

  • Method

    Astrocytes are mock-infected, treated with DMSO or treated with 2 μM niclosamide, 92 μM PHA-690509, 9 μM emricasan (IDN-6556), or a combination of 92 μM PHA-690509 and this compound for 1 h before infection with PRVABC59 (MOI = 0.5). Cells are fixed 24 h after infection and stained for ZIKVE and nuclei.
Animal Study:[1]
  • Animal Models

    C57BL/6J mice

  • Dosages

    0.3mg/kg/day

  • Administration

    i.g.

References

  • https://pubmed.ncbi.nlm.nih.gov/24750664/
  • https://pubmed.ncbi.nlm.nih.gov/27571349/

Selleck's Emricasan (IDN-6556) Has Been Cited by 82 Publications

SIGLEC12 mediates plasma membrane rupture during necroptotic cell death [ Nature, 2025, 10.1038/s41586-025-09741-1] PubMed: 41225007
Inhibition of heme biosynthesis triggers cuproptosis in acute myeloid leukemia [ Cell, 2025, S0092-8674(25)01233-4] PubMed: 41265435
WNK1 mediates M-CSF-induced macropinocytosis to enforce macrophage lineage fidelity [ Nat Commun, 2025, 16(1):4945] PubMed: 40436823
RIPK1 autophosphorylation at S161 mediates cell death and inflammation [ J Exp Med, 2025, 222(12)e20250279] PubMed: 40996439
IFNγ augments TKI efficacy by alleviating protein unfolding stress to promote GSDME-mediated pyroptosis in hepatocellular carcinoma [ Cell Death Dis, 2025, 16(1):512] PubMed: 40645933
Establishment of bovine extraembryonic endoderm stem cells enables efficient blastoid formation [ Cell Rep, 2025, 44(6):115707] PubMed: 40402743
Pan-caspase inhibitors induce secretion of HIV-1 latency reversal agent lymphotoxin-alpha from cytokine-primed NK cells [ Cell Death Discov, 2025, 11(1):44] PubMed: 39905001
Caspase cleavage of Kaposi sarcoma-associated herpesvirus proteins: a role for K5 in preventing caspase-mediated cell death during lytic replication [ J Virol, 2025, 99(9):e0062225] PubMed: 40882004
Neuroligin-3 R451C induces gain-of-function gene expression in astroglia in an astroglia-enriched brain organoid model [ Cell Regen, 2025, 14(1):1] PubMed: 39775628
Morphogen-guided neocortical organoids recapitulate regional areal identity and model neurodevelopmental disorder pathology [ bioRxiv, 2025, 2025.09.02.672952] PubMed: 40950130

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SHIPPING AND STORAGE
Selleck products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Selleck Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Selleck products are stable under the recommended conditions.

NOT FOR HUMAN, VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.